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Ferraro et al (1996) in the 1st of a series of papers about modafinil’s steps confirmed applying in vivo microdialysis in rats that modafinil decreases GABA while in the medial preoptic spot with the hypothalamus plus the posterior hypothalamus.Madras et al (2006) inside of a the latest paper shown in vivo binding of modafinil to striatal DAT and